Kuan, Valerie and Warwick, Alasdair and Hingorani, Aroon and Tufail, Adnan and Cipriani, Valentina and Burgess, Stephen and Sofat, Reecha (2021) Association of smoking, alcohol consumption, blood pressure, body mass index, and glycemic risk factors with age-related macular degeneration: a Mendelian randomization study. JAMA Ophthalmology, 139, (12), pp. 1299-1306. 10.1001/jamaophthalmol.2021.4601.
External website: https://jamanetwork.com/journals/jamaophthalmology...
Question: Are smoking, alcohol intake, blood pressure, body mass index, and glycemic traits associated with age-related macular degeneration (AMD)?
Findings: In this mendelian randomization study, genetically predicted smoking initiation and lifetime smoking were associated with elevated risk of advanced AMD, genetically predicted smoking cessation was associated with decreased risk of advanced AMD, and genetically predicted alcohol intake was associated with increased risk of geographic atrophy.
Meaning: These findings support a potential causal association of alcohol consumption with an increased risk of geographic atrophy, smoking initiation and lifetime smoking with an increased risk of advanced AMD, and smoking cessation with a decreased risk of advanced AMD.
A Substance use and dependence > Effects or consequences
B Substances > Alcohol
B Substances > Tobacco (cigarette smoking)
G Health and disease > State of health > Physical health
T Demographic characteristics > Elderly / Older person
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