Odendaal, Hein and Dukes, Kimberly A and Elliott, Amy J and Willinger, Marian and Sullivan, Lisa M and Tripp, Tara and Groenewald, Coen and Myers, Michael M and Fifer, William P and Angal, Jyoti and Boyd, Theonia K and Burd, Larry and Cotton, Jacob B and Folkerth, Rebecca D and Hankins, Gary and Haynes, Robin L and Hoffman, Howard J and Jacobs, Perri K and Petersen, Julie and Pini, Nicolò and Randall, Bradley B and Roberts, Drucilla J and Robinson, Fay and Sens, Mary A and Van Eerden, Peter and Wright, Colleen and Holm, Ingrid A and Kinney, Hannah C (2021) Association of prenatal exposure to maternal drinking and smoking with the risk of stillbirth. JAMA Network Open, 4, (8), e2121726. doi: 10.1001/jamanetworkopen.2021.21726.
External website: https://jamanetwork.com/journals/jamanetworkopen/f...
Key points:
Question: Is prenatal exposure to maternal drinking and smoking associated with the risk of stillbirth?
Findings: In this cohort study of 8506 pregnant women (with 11 892 pregnancies) in Cape Town, South Africa, and the Northern Plains in the US, dual exposure to drinking and smoking after the first trimester of pregnancy had 2.78 times the risk of late stillbirth compared with those with no exposure or who had quit before the end of the first trimester of pregnancy.
Meaning: These findings suggest that dual exposure to drinking and smoking after the first trimester of pregnancy is associated with nearly 3 times the risk of late stillbirth.
B Substances > Alcohol
B Substances > Tobacco (cigarette smoking)
E Concepts in biomedical areas > Pregnancy
G Health and disease > Substance use disorder > Multiple substance use (Poly-drug /Poly-substance)
G Health and disease > Disease by cause (Aetiology) > Foetal, infant, newborn diseases (reproductive effects)
T Demographic characteristics > Pregnant woman
VA Geographic area > International
VA Geographic area > Africa > South Africa
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