Home > Residual effects of cannabis-use on neuropsychological functioning.

Kristin Wendel, Lena and Daedelow, Laura and Kaminski, Jakob and Banaschewski, Tobias and Millenet, Sabina and Bokde, Arun L W and Burke Quinlan, Erin and Desrivières, Sylvane and Flor, Herta and Grigis, Antoine and Garavan, Hugh and Gowland, Penny and Heinz, Andreas and Brühl, Rüdiger and Martinot, Jean-Luc and Artiges, Eric and Nees, Frauke and Papadopoulos Orfanos, Dimitri and Paus, Tomas and Poustka, Luise and Fröhner, Juliane H and Smolka, Michael N and Whelan, Robert and Schumann, Gunter and Walter, Henrik (2021) Residual effects of cannabis-use on neuropsychological functioning. Cognitive Development, 59, p. 101072. https://doi.org/10.1016/j.cogdev.2021.101072.

External website: https://www.researchgate.net/publication/352384549...

Data was obtained from healthy adolescents drawn from the IMAGEN project, a multi-center study conducted in four European countries. At baseline, a cohort of 2316 14-year-olds (1177 females, 1139 males) was recruited from secondary schools.


  • Residual effects of cannabis use on neurocognition remain equivocal with most studies being cross-sectional.
  • Therefore, we conducted one of the largest longitudinal European multicenter studies on the topic.
  • We detected no significant differences in neurocognitive abilities before initiation of cannabis use.
  • Decision making is not impaired when cannabis is used in moderation, and onset of use occurs after the age of 15.
  • Findings highlight the importance of trajectories in cannabis use for neurocognition.

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