Home > Exploring the effect of alcohol on disease activity and outcomes in rheumatoid arthritis through systematic review and meta-analysis.

Turk, Jaime N and Zahavi, Erin R and Gorman, Aine E and Murray, Kieran and Turk, Matthew A and Veale, Douglas J (2021) Exploring the effect of alcohol on disease activity and outcomes in rheumatoid arthritis through systematic review and meta-analysis. Scientific Reports, 11, (1), p. 10474. https://doi.org/10.1038/s41598-021-89618-1.

External website: https://www.nature.com/articles/s41598-021-89618-1

To evaluate the effects of alcohol consumption on disease activity in rheumatoid arthritis. EMBASE, Pubmed, the Cochrane Library, and Web of Science were searched until July 29, 2020. English language studies that reported disease activity outcomes in rheumatoid arthritis were included. Studies were excluded if they were reviews, case reports, had fewer than 20 patients, or reported on prevalence but not disease activity in RA. Forest plots were used to determine pooled mean difference and were generated on RevMan5.3. Linear regression was used to determine correlations between alcohol and antibody status, gender, and smoking status. The search identified 4126 citations of which 14 were included. The pooled mean difference in DAS28 (95% CI) was 0.34 (0.24, 0.44) (p < 10) between drinkers and non-drinkers with lower DAS28 in non-drinkers, 0.33 (0.05, 0.62) (p = 0.02) between heavy drinkers and non-drinkers with lower DAS28 in heavy drinkers, and 0.00 (- 0.30, 0.30) (p = 0.98) between low- and high-risk drinkers. The mean difference of HAQ assessments was significantly different between those who drink alcohol compared to those who do not, with drinkers reporting lower HAQ scores (0.3 (0.18, 0.41), p < 10). There was no significant correlation between drinking and gender, smoking status, or antibody positivity. Alcohol consumption is associated with lower disease activity and self-reported health assessment in rheumatoid arthritis. However, drinking has no correlation with smoking, gender, or antibody status.


Item Type
Article
Publication Type
Irish-related, Open Access, Article
Drug Type
Alcohol
Intervention Type
Prevention, Harm reduction
Date
2021
Identification #
https://doi.org/10.1038/s41598-021-89618-1
Page Range
p. 10474
Publisher
Nature Publishing Group
Volume
11
Number
1
EndNote
Accession Number
HRB (Electronic Only)

Repository Staff Only: item control page