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Home > Alcohol drinking and head and neck cancer risk: the joint effect of intensity and duration.

Di Credico, Gioia and Polesel, Jerry and Dal Maso, Luigino and Pauli, Francesco and Torelli, Nicola and Luce, Daniele and Radoï, Loredana and Matsuo, Keitaro and Serraino, Diego and Brennan, Paul and Holcatova, Ivana and Ahrens, Wolfgang and Lagiou, Pagona and Canova, Cristina and Richiardi, Lorenzo and Healy, Claire M and Kjaerheim, Kristina and Conway, David I and Macfarlane, Gary J and Thomson, Peter and Agudo, Antonio and Znaor, Ariana and Franceschi, Silvia and Herrero, Rolando and Toporcov, Tatiana N and Moyses, Raquel A and Muscat, Joshua and Negri, Eva and Vilensky, Marta and Fernandez, Leticia and Curado, Maria Paula and Menezes, Ana and Daudt, Alexander W and Koifman, Rosalina and Wunsch-Filho, Victor and Olshan, Andrew F and Zevallos, Jose P and Sturgis, Erich M and Li, Guojun and Levi, Fabio and Zhang, Zuo-Feng and Morgenstern, Hal and Smith, Elaine and Lazarus, Philip and La Vecchia, Carlo and Garavello, Werner and Chen, Chu and Schwartz, Stephen M and Zheng, Tongzhang and Vaughan, Thomas L and Kelsey, Karl and McClean, Michael and Benhamou, Simone and Hayes, Richard B and Purdue, Mark P and Gillison, Maura and Schantz, Stimson and Yu, Guo-Pei and Chuang, Shu-Chun and Boffetta, Paolo and Hashibe, Mia and Yuan-Chin, Amy Lee and Edefonti, Valeria (2020) Alcohol drinking and head and neck cancer risk: the joint effect of intensity and duration. British Journal of Cancer, 123, (9), pp. 1456-1463. doi: 10.1038/s41416-020-01031-z.

External website: https://air.unimi.it/retrieve/handle/2434/784552/1...

BACKGROUND: Alcohol is a well-established risk factor for head and neck cancer (HNC). This study aims to explore the effect of alcohol intensity and duration, as joint continuous exposures, on HNC risk.

METHODS: Data from 26 case-control studies in the INHANCE Consortium were used, including never and current drinkers who drunk ≤10 drinks/day for ≤54 years (24234 controls, 4085 oral cavity, 3359 oropharyngeal, 983 hypopharyngeal and 3340 laryngeal cancers). The dose-response relationship between the risk and the joint exposure to drinking intensity and duration was investigated through bivariate regression spline models, adjusting for potential confounders, including tobacco smoking.

RESULTS: For all subsites, cancer risk steeply increased with increasing drinks/day, with no appreciable threshold effect at lower intensities. For each intensity level, the risk of oral cavity, hypopharyngeal and laryngeal cancers did not vary according to years of drinking, suggesting no effect of duration. For oropharyngeal cancer, the risk increased with durations up to 28 years, flattening thereafter. The risk peaked at the higher levels of intensity and duration for all subsites (odds ratio = 7.95 for oral cavity, 12.86 for oropharynx, 24.96 for hypopharynx and 6.60 for larynx).

CONCLUSIONS: Present results further encourage the reduction of alcohol intensity to mitigate HNC risk.


Item Type
Article
Publication Type
International, Article
Drug Type
Alcohol
Intervention Type
Harm reduction
Date
October 2020
Identification #
doi: 10.1038/s41416-020-01031-z
Page Range
pp. 1456-1463
Volume
123
Number
9
EndNote
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