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Home > Alcohol consumption, cardiac biomarkers, and risk of atrial fibrillation and adverse outcomes.

Csengeri, Dora and Sprünker, Ngoc-Anh and Di Castelnuovo, Augusto and Niiranen, Teemu and Vishram-Nielsen, Julie Kk and Costanzo, Simona and Söderberg, Stefan and Jensen, Steen M and Vartiainen, Erkki and Donati, Maria Benedetta and Magnussen, Christina and Camen, Stephan and Gianfagna, Francesco and Løchen, Maja-Lisa and Kee, Frank and Kontto, Jukka and Mathiesen, Ellisiv B and Koenig, Wolfgang and Stefan, Blankenberg and de Gaetano, Giovanni and Jørgensen, Torben and Kuulasmaa, Kari and Zeller, Tanja and Salomaa, Veikko and Iacoviello, Licia and Schnabel, Renate B (2021) Alcohol consumption, cardiac biomarkers, and risk of atrial fibrillation and adverse outcomes. European Heart Journal, 42, (12), pp. 1170-1177. https://doi.org/10.1093/eurheartj/ehaa953.

External website: https://academic.oup.com/eurheartj/article/42/12/1...

AIMS 
There is inconsistent evidence on the relation of alcohol intake with incident atrial fibrillation (AF), in particular at lower doses. We assessed the association between alcohol consumption, biomarkers, and incident AF across the spectrum of alcohol intake in European cohorts.

METHODS AND RESULTS 
In a community-based pooled cohort, we followed 107 845 individuals for the association between alcohol consumption, including types of alcohol and drinking patterns, and incident AF. We collected information on classical cardiovascular risk factors and incident heart failure (HF) and measured the biomarkers N-terminal pro-B-type natriuretic peptide and high-sensitivity troponin I. The median age of individuals was 47.8 years, 48.3% were men. The median alcohol consumption was 3 g/day. N = 5854 individuals developed AF (median follow-up time: 13.9 years). In a sex- and cohort-stratified Cox regression analysis alcohol consumption was non-linearly and positively associated with incident AF. The hazard ratio for one drink (12 g) per day was 1.16, 95% CI 1.11-1.22, P < 0.001. Associations were similar across types of alcohol. In contrast, alcohol consumption at lower doses was associated with reduced risk of incident HF. The association between alcohol consumption and incident AF was neither fully explained by cardiac biomarker concentrations nor by the occurrence of HF.

CONCLUSIONS 
In contrast to other cardiovascular diseases such as HF, even modest habitual alcohol intake of 1.2 drinks/day was associated with an increased risk of AF, which needs to be considered in AF prevention.


Item Type
Article
Publication Type
International, Open Access, Article
Drug Type
Alcohol
Intervention Type
Prevention, Harm reduction
Date
21 March 2021
Identification #
https://doi.org/10.1093/eurheartj/ehaa953
Page Range
pp. 1170-1177
Publisher
Oxford Academic
Volume
42
Number
12
EndNote

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