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Home > Does 'Dry Hit' vaping of vitamin E acetate contribute to EVALI? Simulating toxic ketene formation during e-cigarette use.

Narimani, Milad and da Silva, Gabriel . (2020) Does 'Dry Hit' vaping of vitamin E acetate contribute to EVALI? Simulating toxic ketene formation during e-cigarette use. PLoS ONE, 15 (9) e0238140. doi: 10.1371/journal.pone.0238140

URL: https://journals.plos.org/plosone/article?id=10.13...

Vitamin E acetate (VEA) is strongly linked to the outbreak of electronic-cigarette or vaping product use-associated lung injury (EVALI). It has been proposed that VEA decomposition to ketene-a respiratory poison that damages lungs at low ppm levels-may play a role in EVALI. However, there is no information available on the temperature at which VEA decomposes and how this correlates with the vaping process. We have studied the temperature-dependent kinetics of VEA decomposition using quantum chemical and statistical mechanical modelling techniques, developing a chemical kinetic model of the vaping process.

This model predicts that, under typical vaping conditions, the use of VEA contaminated e-cigarette products is unlikely to produce ketene at harmful levels. However, at the high temperatures encountered at low e-cigarette product levels, which produce 'dry hits', ketene concentrations are predicted to reach acutely toxic levels in the lungs (as high as 30 ppm). We therefore hypothesize that dry hit vaping of e-cigarette products containing VEA contributes to EVALI.


Item Type
International research
Publication Type
Open Access, Article
Drug Type
Tobacco / Nicotine
Intervention Type
Harm reduction
Date
2020
Identification #
doi: 10.1371/journal.pone.0238140
Pages
e0238140
Page Range
e0238140
Volume
15
Number
9
EndNote

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