Electronic nicotine and non-nicotine delivery systems (EN&NNDS) are a heterogeneous class of products that use an electrically powered coil to heat and turn a liquid into an aerosol, which is inhaled by the user. Throughout the world, governments use different approaches to regulate EN&NNDS in their marketplace. This brief provides examples of the three more typical regulatory approaches, including banning the sale of EN&NNDS, applying tobacco-control legislation to these products, and creating an elaborate group of specific regulations or recommendations related to the sale, marketing, packaging, product regulation, reporting/ notification, taxation and use in workplaces and public places.