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Home > Treatment of stimulant use disorder: a systematic review of reviews.

Ronsley, Claire and Nolan, Seonaid and Knight, Rod and Hayashi, Kanna and Klimas, Jano and Walley, Alex and Wood, Evan and Fairbairn, Nadia . (2020) Treatment of stimulant use disorder: a systematic review of reviews. PloS one, 15 (6) e02348.

URL: https://journals.plos.org/plosone/article?id=10.13...

AIMS
Stimulant use disorder contributes to a substantial worldwide burden of disease, although evidence-based treatment options are limited. This systematic review of reviews aims to: (i) synthesize the available evidence on both psychosocial and pharmacological interventions for the treatment of stimulant use disorder; (ii) identify the most effective therapies to guide clinical practice, and (iii) highlight gaps for future study.

METHODS
A systematic database search was conducted to identify systematic reviews and meta-analyses. Eligible studies were those that followed standard systematic review methodology and assessed randomized controlled trials focused on the efficacy of interventions for stimulant use disorder. Articles were critically appraised using an assessment tool adapted from Palmeteer et al. and categorized for quality as 'core' or 'supplementary' reviews. Evidence from the included reviews were further synthesized according to pharmacological or non-pharmacological management themes.

RESULTS
Of 476 identified records, 29 systematic reviews examining eleven intervention modalities were included. The interventions identified include: contingency management, cognitive behavioural therapy, acupuncture, antidepressants, dopamine agonists, antipsychotics, anticonvulsants, disulfiram, opioid agonists, N-Acetylcysteine, and psychostimulants. There was sufficient evidence to support the efficacy of contingency management programs for treatment of stimulant use disorder. Psychostimulants, n-acetylcysteine, opioid agonist therapy, disulfiram and antidepressant pharmacological interventions were found to have insufficient evidence to support or discount their use. Results of this review do not support the use of all other treatment options.

CONCLUSIONS
The results of this review supports the use of contingency management interventions for the treatment of stimulant use disorder. Although evidence to date is insufficient to support the clinical use of psychostimulants, our results demonstrate potential for future research in this area. Given the urgent need for effective pharmacological treatments for stimulant use disorder, high-quality primary research focused on the role of psychostimulant medications for the treatment of stimulant use disorder is needed.


Item Type
Evidence resource
Publication Type
Review
Drug Type
CNS stimulants
Date
2020
Pages
e02348
Page Range
e0234809
Volume
15
Number
6
EndNote
Accession Number
HRB (Electronic Only)

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