Question: Does the association between vaping uptake and subsequent smoking differ between individuals favoring tobacco- vs nontobacco-flavored e-cigarettes?

Findings: In this cohort study with 17 929 participants, multivariable analyses of nationally representative, longitudinal survey data evaluated differences in smoking initiation and cessation subsequent to vaping uptake among those who used flavored vs unflavored e-cigarettes, separately by age group. Relative to vaping tobacco flavors, vaping nontobacco-flavored e-cigarettes was not associated with increased youth smoking initiation but was associated with an increase in the odds of adult smoking cessation.

Meaning: In this study, adults who vaped flavored e-cigarettes were more likely to subsequently quit smoking than those who used unflavored e-cigarettes.