Home > Clinical question: Can adding baclofen to psychosocial treatment improve outcomes for people with alcohol use disorder?

Kavirajan, Harish (2019) Clinical question: Can adding baclofen to psychosocial treatment improve outcomes for people with alcohol use disorder? Cochrane Clinical Answers, https://doi.org/10.1002/cca.2457.

External website: https://www.cochranelibrary.com/cca/doi/10.1002/cc...


Not only have clinical trials failed to demonstrate benefits over placebo from adding baclofen to psychosocial treatment for alcohol use disorder, they have also suggested that baclofen increases rates of various adverse events such as dizziness, somnolence, paresthesias, and muscle spasms/rigidity. Despite elevated rates of such adverse events, rates of withdrawal due to adverse events or for any cause were similar in both groups.

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