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Home > Predicting development of adolescent drinking behaviour from whole brain structure at 14 years of age.

Kühn, Simone and Mascharek, Anna and Banaschewski, Tobias and Bodke, Arun and Bromberg, Uli and Büchel, Christian and Quinlan, Erin Burke and Desrivieres, Sylvane and Flor, Herta and Grigis, Antoine and Garavan, Hugh and Gowland, Penny A and Heinz, Andreas and Ittermann, Bernd and Martinot, Jean-Luc and Nees, Frauke and Papadopoulos Orfanos, Dimitri and Paus, Tomas and Poustka, Luise and Millenet, Sabina and Fröhner, Juliane H and Smolka, Michael N and Walter, Henrik and Whelan, Robert and Schumann, Gunter and Lindenberger, Ulman and Gallinat, Jürgen (2019) Predicting development of adolescent drinking behaviour from whole brain structure at 14 years of age. eLife, 8, . DOI: 10.7554/eLife.44056.

External website: https://elifesciences.org/articles/44056

Adolescence is a common time for initiation of alcohol use and development of alcohol use disorders. The present study investigates neuroanatomical predictors for trajectories of future alcohol use based on a novel voxel-wise whole-brain structural equation modeling framework. In 1814 healthy adolescents of the IMAGEN sample, the Alcohol Use Disorder Identification Test (AUDIT) was acquired at three measurement occasions across five years. Based on a two-part latent growth curve model, we conducted whole-brain analyses on structural MRI data at age 14, predicting change in alcohol use score over time. Higher grey-matter volumes in the caudate nucleus and the left cerebellum at age 14 years were predictive of stronger increase in alcohol use score over 5 years. The study is the first to demonstrate the feasibility of running separate voxel-wise structural equation models thereby opening new avenues for data analysis in brain imaging.


Item Type
Article
Publication Type
International, Open Access, Article
Drug Type
Alcohol
Intervention Type
Screening / Assessment
Date
2019
Identification #
DOI: 10.7554/eLife.44056
Publisher
eLife Sciences Publications Ltd
Volume
8
EndNote
Accession Number
HRB (Electronic Only)

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