There is high‐certainty evidence that combination NRT (fast‐acting form plus patch) results in higher long‐term quit rates than single form (risk ratio (RR) 1.27, 95% confidence interval (CI) 1.17 to 1.37; I2 = 12%; 16 studies, 12,169 participants). Moderate‐certainty evidence, limited by imprecision, indicates that 42/44 mg patches are as effective as 21/22 mg (24‐hour) patches (RR 1.09, 95% CI 0.93 to 1.29; I2 = 38%; 5 studies, 1655 participants), and that 21 mg patches are more effective than 14 mg (24‐hour) patches (RR 1.48, 95% CI 1.06 to 2.08; 1 study, 537 participants). Moderate‐certainty evidence, again limited by imprecision, also suggests a benefit of 25 mg over 15 mg (16‐hour) patches, but the lower limit of the CI encompassed no difference (RR 1.19, 95% CI 1.00 to 1.41; I2 = 0%; 3 studies, 3446 participants).