Home > Different doses, durations and modes of delivery of nicotine replacement therapy for smoking cessation.

Lindson, Nicola and Chepkin, Samantha C and Ye, Weiyu and Fanshawe, Thomas R and Bullen, Chris and Hartmann-Boyce, Jamie [The Cochrane Library] . (2019) Different doses, durations and modes of delivery of nicotine replacement therapy for smoking cessation. Wiley. Cochrane Database of Systematic Reviews (4)

URL: https://www.cochranelibrary.com/cdsr/doi/10.1002/1...

There is high‐certainty evidence that using combination NRT versus single‐form NRT, and 4 mg versus 2 mg nicotine gum, can increase the chances of successfully stopping smoking. For patch dose comparisons, evidence was of moderate certainty, due to imprecision. Twenty‐one mg patches resulted in higher quit rates than 14 mg (24‐hour) patches, and using 25 mg patches resulted in higher quit rates than using 15 mg (16‐hour) patches, although in the latter case the CI included one. There was no clear evidence of superiority for 42/44 mg over 21/22 mg (24‐hour) patches. Using a fast‐acting form of NRT, such as gum or lozenge, resulted in similar quit rates to nicotine patches. There is moderate‐certainty evidence that using NRT prior to quitting may improve quit rates versus using it from quit date only; however, further research is needed to ensure the robustness of this finding. Evidence for the comparative safety and tolerability of different types of NRT use is of low and very low certainty. New studies should ensure that AEs, SAEs and withdrawals due to treatment are both measured and reported.


Item Type:Evidence resource
Publication Type:Review
Drug Type:Tobacco
Intervention Type:AOD disorder drug therapy, AOD disorder harm reduction
Source:The Cochrane Library
Date:April 2019
Publisher:Wiley
Number:4
EndNote:View
Subjects:B Substances > Tobacco (cigarette smoking)
B Substances > Tobacco (cigarette smoking) > Nicotine product (e-cigarette / vaping)
HJ Treatment method > Substance disorder treatment method > Cessation of substance use

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