This is the first Programming Document fully grounded in the EMCDDA Strategy 2025 and it sets a milestone in the strategic and operational planning framework of the EMCDDA. Among the highlights for this period will be a follow up on the outcome of the fourth external evaluation of the EMCDDA. An ongoing priority will be the implementation of the EU Early Warning System on new psychoactive substances (EU EWS). A comprehensive overview of new, changing or emerging threats will be provided by the third strategic analysis EU Drug Markets Report that will be launched jointly with Europol in 2019.