Home > Cannabinoid and nicotine exposure during adolescence induces sex-specific effects on anxiety- and reward-related behaviors during adulthood.

Pushkin, Anna N and Eugene, Angeline J and Lallai, Valeria and Torres-Mendoza, Alan and Fowler, J P and Chen, Edison and Fowler, Christie D [PLOS One] . (2019) Cannabinoid and nicotine exposure during adolescence induces sex-specific effects on anxiety- and reward-related behaviors during adulthood. Public Library of Science. PLoS ONE, 14 (1)

URL: https://journals.plos.org/plosone/article?id=10.13...

Nicotine and cannabis use during adolescence has the potential to induce long lasting changes on affective and cognitive function. Here, we examined whether adolescent exposure to nicotine, the cannabinoid agonist WIN55-212,2 (WIN), or co-exposure to both would alter operant learning, locomotion, and anxiety- and reward-related behaviors in male and female mice during adulthood. Males exposed to a moderate dose of WIN (2 mg/kg) or co-exposed to nicotine and the moderate dose of WIN exhibited decreased anxiety-associated behaviors and increased cognitive flexibility, but did not differ in operant learning or generalized locomotion. In contrast, differences were not found among the females in these measures at the moderate WIN dose or in both sexes with exposure to a low WIN dose (0.2 mg/kg). Furthermore, a sex-dependent dissociative effect was found in natural reward consumption. Males exposed to the moderate dose of WIN or co-exposed to nicotine and the moderate dose of WIN demonstrated increased sucrose consumption. In contrast, females exposed to the moderate dose of WIN exhibited a decrease in sucrose consumption, which was ameliorated with co-administration of nicotine.

Together, these novel findings demonstrate that adolescent exposure to cannabinoids in the presence or absence of nicotine results in altered affective and reward-related behaviors during adulthood.


Item Type:Evidence resource
Drug Type:Cannabis, Tobacco
Intervention Type:AOD disorder, AOD disorder harm reduction
Source:PLOS One
Date:January 2019
Page Range:e0211346
Publisher:Public Library of Science
Volume:14
Number:1
EndNote:View
Subjects:A Substance use, abuse, and dependence > Effects and consequences
B Substances > Cannabis / Marijuana
B Substances > Tobacco (cigarette smoking)
B Substances > Tobacco (cigarette smoking) > Nicotine product (e-cigarette / vaping)
F Concepts in psychology > Emotion (anxiety, emotional pain)
F Concepts in psychology > Attitude and behaviour > Behaviour
T Demographic characteristics > Man (men / male)
T Demographic characteristics > Adolescent / youth (teenager / young person)
T Demographic characteristics > Gender differences

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