Home > Clinical question: How do single over‐the‐counter nicotine replacement therapy (NRT) agents compare with placebo/no NRT agents for smoking cessation?

Kavirajan, Harish (2018) Clinical question: How do single over‐the‐counter nicotine replacement therapy (NRT) agents compare with placebo/no NRT agents for smoking cessation? Cochrane Clinical Answers,

External website: https://www.cochranelibrary.com/cca/doi/10.1002/cc...


Various forms of single over‐the‐counter nicotine replacement agents appear to be superior to placebo/no agents in promoting smoking cessation at six months’ or longer follow‐up. Although reviewers identified many RCTs including around 50,000 participants, approximately two‐thirds of trials were at risk of bias because of weak randomization and blinding processes and lack of follow‐up of participants.

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