Agabio, Roberta and Saulle, Rosella and Rosner, Susanne and Minozzi, Silvia (2023) Baclofen for alcohol use disorder. Cochrane Database of Systematic Reviews, (1), https://doi.org/10.1002/14651858.CD012557.pub3.
External website: https://www.cochranelibrary.com/cdsr/doi/10.1002/1...
Authors' conclusions:
Baclofen likely reduces the risk of relapse to any drinking and increases the percentage of abstinent days, mainly among detoxified participants. It does not increase the number of participants with at least one adverse event, those who dropout for any reason or due to adverse events. It probably does not reduce number of heavy drinking days and the number of drinks per drinking days. Current evidence suggests that baclofen may help people with AUD in maintaining abstinence. The results of comparisons of baclofen with acamprosate and naltrexone were mainly based on only one study.
G Health and disease > Substance use disorder > Alcohol use disorder > Alcohol dependence
HJ Treatment or recovery method > Substance disorder treatment method > Substance disorder drug therapy (pharmacological treatment)
HJ Treatment or recovery method > Substance disorder treatment method > Substance replacement method (substitution)
HJ Treatment or recovery method > Treatment outcome
J Health care, prevention, harm reduction and treatment > Treatment and maintenance > Treatment factors
VA Geographic area > International
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