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Home > Alcoholic hepatitis: a comprehensive review of pathogenesis and treatment.

Chayanupatkul, Maneerat and Liangpunsakul, Suthat . (2014) Alcoholic hepatitis: a comprehensive review of pathogenesis and treatment. World Journal of Gastroenterology, 20 (20) doi: 10.3748/wjg.v20.i20.6279

URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC40334...

Alcoholic hepatitis (AH) is an acute hepatic inflammation associated with significant morbidity and mortality. Current evidence suggests that the pathogenesis is the end result of the complex interplay between ethanol metabolism, inflammation and innate immunity. Several clinical scoring systems have been derived to predict the clinical outcomes of patients with AH; such as Child-Turcotte-Pugh score, the Maddrey discriminant function, the Lille Model, the model for end stage liver disease scores, and the Glasgow alcoholic hepatitis score. At present, Corticosteroids or pentoxifylline are the current pharmacologic treatment options; though the outcomes from the therapies are poor. Liver transplantation as the treatment of alcoholic hepatitis remains controversial, and in an era of organ shortage current guidelines do not recommend transplantation as the treatment option. Because of the limitations in the therapeutic options, it is no doubt that there is a critical need for the newer and more effective pharmacological agents to treat AH.


Item Type
Evidence resource
Publication Type
Guideline
Drug Type
Alcohol
Intervention Type
AOD disorder, AOD disorder harm reduction
Date
28 May 2014
Page Range
pp. 6279-86
Volume
20
Number
20
EndNote

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