When tobacco cessation interventions (individual or group counseling, technology‐based interventions, multicomponent interventions, Project EX, pharmacology) were compared with standard care or no tobacco cessation intervention controls, the only interventions to show clear benefit were group counseling (191 vs 142 per 1000 young people quit smoking) and Project EX (a complex theoretical construct including motivational interviewing, games for groups, education, anger management, yoga, weight control, meditation, assertiveness training, role play, and relapse prevention; absolute values not available). Evidence shows no clear differences between any other intervention and standard care/no intervention, but the quality of evidence for all comparisons when assessed was very low to low, and firm conclusions cannot be drawn regarding any tobacco cessation intervention. Adverse events were not assessed for most comparisons.