Home > Clinical question: What are the effects of glucocorticosteroids and/or pentoxifylline in people with alcohol‐related liver disease?

Burch, Jane and Tort, Sera [The Cochrane Library] . (2017) Clinical question: What are the effects of glucocorticosteroids and/or pentoxifylline in people with alcohol‐related liver disease? London: Wiley. Cochrane Clinical Answers

URL: https://www.cochranelibrary.com/cca/doi/10.1002/cc...

In adults with alcohol‐related liver disease, glucocorticosteroid (GCS) and pentoxifylline, both given alone, were compared with placebo/no intervention; GCS plus pentoxifylline was compared with placebo, GCS alone, or pentoxifylline alone; and pentoxifylline was compared with GCS. Randomized controlled trials reported no clear differences in mortality or the incidence of decompensated cirrhosis for any of these comparisons. More people experienced adverse events with GCS alone or with pentoxifylline alone than with placebo/no intervention (on average, 572 vs 143 per 1000 people, and 373 vs 212 per 1000 people, respectively). Investigators did not report the preferred measure of the number of people experiencing adverse events for the other comparisons; the difference in the number of adverse events experienced by participants cannot be translated into an increase in the number of people experiencing adverse events and therefore is limited in its clinical application. When assessed, the quality of the evidence was very low, and no firm conclusions can be drawn.


Item Type:Evidence resource
Publication Type:Guideline
Drug Type:Alcohol
Intervention Type:AOD disorder, AOD disorder drug therapy, AOD disorder treatment method
Source:The Cochrane Library
Date:21 October 2017
Publisher:Wiley
Place of Publication:London
EndNote:View
Subjects:B Substances > Alcohol
G Health and disease > Substance use disorder > Alcohol use > Alcohol dependence
G Health and disease > Digestive system disorder > Liver disorder
G Health and disease > Digestive system disorder > Liver disorder > Alcoholic hepatitis
G Health and disease > Digestive system disorder > Liver disorder > Liver cirrhosis
HJ Treatment method > Substance disorder treatment method > Substance disorder drug therapy
HJ Treatment method > Treatment outcome
J Health care, prevention and rehabilitation > Patient care management
J Health care, prevention and rehabilitation > Health care administration > Health care quality control
N Communication, information and education > Recommendations or guidelines > Practice / clinical guidelines

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