Ronellenfitsch, Ulrich (2018) Clinical question: What are the benefits and harms of glucocorticosteroids in adults with alcoholic hepatitis? Cochrane Clinical Answers,
External website: https://www.cochranelibrary.com/cca/doi/10.1002/cc...
There were no clear clinically relevant differences between glucocorticosteroid treatment and placebo/no treatment for adults with alcoholic hepatitis for any measured outcome (all‐cause mortality, liver‐related mortality, quality of life, complications, and serious adverse events). However, where quality of the evidence was assessed, this was very low or low. In addition, when scenario analyses were conducted to test for attrition bias (assumptions made about the outcomes for people unavailable for assessment at follow‐up ‐ had an event or not), one scenario led to results in favor of placebo for mortality and serious adverse events, further decreasing confidence in pooled estimates. As a result, no firm conclusions of equivalence can be drawn.
G Health and disease > Digestive system disease > Liver disease > Alcoholic hepatitis
HJ Treatment or recovery method > Substance disorder treatment method > Substance disorder drug therapy (pharmacological treatment)
HJ Treatment or recovery method > Treatment outcome
J Health care, prevention, harm reduction and treatment > Patient / client care management
J Health care, prevention, harm reduction and treatment > Health care administration > Health care quality control
N Communication, information and education > Recommendations > Practice / clinical guidelines
VA Geographic area > International
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