Burch, Jane and Tort, Sera (2016) Clinical question: How do different pharmacological interventions compare for the treatment of alcohol withdrawal syndrome? Cochrane Clinical Answers,
External website: https://www.cochranelibrary.com/cca/doi/10.1002/cc...
High‐quality evidence showed that fewer people had alcohol withdrawal seizures with benzodiazepines when compared with antipsychotics (on average 19 versus 78 per 1000 people). No differences were detected between groups when benzodiazepines were compared with anticonvulsants (moderate‐quality evidence), or when anticonvulsants were compared with antipsychotics (moderate‐quality evidence). In terms of adverse events and withdrawals due to adverse events, no differences were detected between any two drug classes (very low‐ to high‐quality evidence depending on comparison).
The trials comparing benzodiazepines with each other, or anticonvulsants with each other, were far too small to provide clinically meaningful or reliable results.
G Health and disease > Substance use disorder (addiction) > Alcohol use disorder > Alcohol withdrawal / craving
HJ Treatment or recovery method > Substance disorder treatment method > Substance disorder drug therapy (pharmacological treatment)
HJ Treatment or recovery method > Treatment outcome
J Health care, prevention, harm reduction and treatment > Patient / client care management
J Health care, prevention, harm reduction and treatment > Treatment and maintenance > Treatment factors
N Communication, information and education > Recommendations > Practice / clinical guidelines
VA Geographic area > International
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