Home > Clinical question: How do different pharmacological interventions compare for the treatment of alcohol withdrawal syndrome?

Burch, Jane and Tort, Sera [The Cochrane Library] . (2016) Clinical question: How do different pharmacological interventions compare for the treatment of alcohol withdrawal syndrome? London: Wiley. Cochrane Clinical Answers

URL: https://www.cochranelibrary.com/cca/doi/10.1002/cc...

High‐quality evidence showed that fewer people had alcohol withdrawal seizures with benzodiazepines when compared with antipsychotics (on average 19 versus 78 per 1000 people). No differences were detected between groups when benzodiazepines were compared with anticonvulsants (moderate‐quality evidence), or when anticonvulsants were compared with antipsychotics (moderate‐quality evidence). In terms of adverse events and withdrawals due to adverse events, no differences were detected between any two drug classes (very low‐ to high‐quality evidence depending on comparison).

The trials comparing benzodiazepines with each other, or anticonvulsants with each other, were far too small to provide clinically meaningful or reliable results.


Item Type:Evidence resource
Publication Type:Guideline
Drug Type:Alcohol
Intervention Type:AOD disorder, AOD disorder drug therapy, AOD disorder treatment method
Source:The Cochrane Library
Date:2 December 2016
Publisher:Wiley
Place of Publication:London
EndNote:View
Subjects:B Substances > Alcohol
G Health and disease > Substance use disorder > Alcohol use > Alcohol withdrawal syndrome
HJ Treatment method > Substance disorder treatment method > Substance disorder drug therapy
HJ Treatment method > Treatment outcome
J Health care, prevention and rehabilitation > Patient care management
J Health care, prevention and rehabilitation > Treatment and maintenance > Treatment factors
N Communication, information and education > Recommendations or guidelines > Practice / clinical guidelines

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