Home > Clinical question: Can acamprosate (with or without naltrexone) support continued abstinence after detoxification in alcohol‐dependent people?

Cayley, William [The Cochrane Library] . (2014) Clinical question: Can acamprosate (with or without naltrexone) support continued abstinence after detoxification in alcohol‐dependent people? London: Wiley. Cochrane Clinical Answers

URL: https://www.cochranelibrary.com/cca/doi/10.1002/cc...

Randomized controlled trials suggest that acamprosate may be more effective than placebo for reducing return to drinking but may increase diarrhea. Acamprosate and naltrexone seem to be equally effective but naltrexone seems to cause a wider range of adverse effects. Adding naltrexone to acamprosate did not confer additional benefit and increased adverse effects.....


Item Type:Evidence resource
Publication Type:Guideline
Drug Type:Alcohol
Intervention Type:AOD disorder, AOD disorder drug therapy, AOD disorder treatment method
Source:The Cochrane Library
Date:16 December 2014
Publisher:Wiley
Place of Publication:London
EndNote:View
Subjects:A Substance use, abuse, and dependence > Prevalence > Substance use behaviour > Abstinence
B Substances > Alcohol
B Substances > Opioids (opiates) > Opioid product > Naltrexone
G Health and disease > Substance use disorder > Alcohol use > Alcohol dependence
HJ Treatment method > Substance disorder treatment method > Substance disorder drug therapy
J Health care, prevention and rehabilitation > Patient care management
J Health care, prevention and rehabilitation > Health care delivery
J Health care, prevention and rehabilitation > Health care administration > Health care quality control
N Communication, information and education > Recommendations or guidelines > Practice / clinical guidelines

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