Home > Clinical question: How does pentoxifylline affect outcomes in people with alcoholic hepatitis?

Gruenebaum, Dane . (2015) Clinical question: How does pentoxifylline affect outcomes in people with alcoholic hepatitis? London: Wiley. Cochrane Clinical Answers

URL: https://www.cochranelibrary.com/cca/doi/10.1002/cc...

Low‐to‐moderate quality evidence suggests there may be a mortality benefit to adding pentoxifylline to standard care in alcoholic hepatitis patients, at the cost of increased adverse effects and a higher withdrawal rate.

When comparing standard care alone with adding pentoxifylline or adding placebo to standard care, there was a reduction in mortality at 1‐6 months (257 per 1000 people taking pentoxifylline died vs. 400 per 1000 people taking placebo). Similarly hepatic‐related mortality at 1‐6 months was lower in people taking pentoxifylline (169 per 1000 people taking pentoxifylline died of hepatic complications vs. 423 per 1000 people taking placebo). Hepatic‐related morbidity (variceal bleeds at 1 month) was reported by two of the RCT including 132 patients and there were similar rates in both groups. Two trials with around 100 patients reported adverse effects, one reporting 33 events in people taking pentoxifylline vs. 15 events in people taking placebo, the other reporting a higher withdrawal rate with pentoxifylline (15% vs. 2%).

None of the trials assessed quality of life.


Item Type:Evidence resource
Publication Type:Guideline
Drug Type:Alcohol
Intervention Type:AOD disorder, AOD disorder drug therapy, AOD disorder treatment method
Date:14 September 2015
Publisher:Wiley
Place of Publication:London
EndNote:View
Subjects:B Substances > Alcohol
G Health and disease > State of health > Physical health
G Health and disease > Digestive system disorder > Liver disorder > Alcoholic hepatitis
HJ Treatment method > Substance disorder treatment method > Substance disorder drug therapy
HJ Treatment method > Treatment outcome
J Health care, prevention and rehabilitation > Patient care management
J Health care, prevention and rehabilitation > Treatment and maintenance > Treatment factors
J Health care, prevention and rehabilitation > Health care administration > Health care quality control
N Communication, information and education > Recommendations or guidelines > Practice / clinical guidelines

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