Home > Antidepressants for the treatment of people with co-occurring depression and alcohol dependence.

Agabio, Roberta and Trogu, Emanuela and Pani, Pier Paolo [The Cochrane Library] . (2018) Antidepressants for the treatment of people with co-occurring depression and alcohol dependence. John Wiley & Sons, Ltd. Cochrane Database of Systematic Reviews (4) DOI: 10.1002/14651858.CD008581.pub2

URL: http://cochranelibrary-wiley.com/doi/10.1002/14651...

We found low-quality evidence supporting the clinical use of antidepressants in the treatment of people with co-occurring depression and alcohol dependence. Antidepressants had positive effects on certain relevant outcomes related to depression and alcohol use but not on other relevant outcomes. Moreover, most of these positive effects were no longer significant when studies with high risk of bias were excluded. Results were limited by the large number of studies showing high or unclear risk of bias and the low number of studies comparing one antidepressant to another or antidepressants to other medication. In people with co-occurring depression and alcohol dependence, the risk of developing adverse effects appeared to be minimal, especially for the newer classes of antidepressants (such as selective serotonin reuptake inhibitors). According to these results, in people with co-occurring depression and alcohol dependence, antidepressants may be useful for the treatment of depression, alcohol dependence, or both, although the clinical relevance may be modest.


Item Type:Evidence resource
Publication Type:Review
Drug Type:Alcohol
Intervention Type:AOD disorder, AOD disorder drug therapy, AOD disorder treatment method
Source:The Cochrane Library
Date:April 2018
Publisher:John Wiley & Sons, Ltd
Number:4
EndNote:View
Subjects:B Substances > Alcohol
G Health and disease > State of health > Mental health
G Health and disease > Substance related disorder > Dual diagnosis (comorbidity)
G Health and disease > Substance use disorder > Alcohol use > Alcohol dependence
HJ Treatment method > Substance disorder treatment method > Substance disorder drug therapy
J Health care, prevention and rehabilitation > Patient care management
J Health care, prevention and rehabilitation > Care by type of problem > Mental health care

Repository Staff Only: item control page