Key points from summary and commentary:
In 2013 nalmefene was authorised for moderating drinking among patients not in need of detoxification, extending pharmacotherapy to less dependent drinkers.

The featured review examined whether other medications (naltrexone, acamprosate, baclofen, and topiramate) have been found to do this just as well.

There was no high quality evidence for any of the medications, though nalmefene, topiramate and baclofen moderated consumption, and topiramate also consistently reduced other measures of drinking. No evidence was found that nalmefene was superior to the other medications, or that any improved health.

Safety concerns mean topiramate and baclofen are not recommended for alcohol dependence in the UK.