Home > Non-medical use of olanzapine by people on methadone treatment.

James, Philip David and Fida, Ali Shaik and Konovalov, Pavel and Smyth, Bobby P (2016) Non-medical use of olanzapine by people on methadone treatment. BJPsych Bulletin, 40, (6), pp. 314-317. doi: 10.1192/pb.bp.115.052886.

External website: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC53535...

Aims and method We examined non-medical use (NMU) of olanzapine among adults on methadone treatment. Information was collected on patient demographics and NMU of olanzapine. The Alcohol, Smoking and Substance Involvement Screening Test (ASSIST) was administered to assess risk among current users of olanzapine. Results Ninety-two clients participated and 30% reported lifetime history of NMU of olanzapine. Nine people reported doses of 30 mg or higher on a typical day of use, with three typically using 100 mg. The most common reasons for use were to relieve anxiety and to aid sleep, but a quarter used it to 'get stoned'. Eleven participants (12%) reported NMU of olanzapine in the preceding month. Eight completed the ASSIST with four scoring in the high-risk zone. Clinical implications Self-medication is the dominant motivator for NMU of olanzapine, but hedonic motivations also occur. A small minority show features of dependency. All doctors should be aware of the potential NMU of olanzapine, especially among patients with history of addiction.

Item Type
Publication Type
Irish-related, Open Access, Article
Drug Type
CNS depressants / Sedatives, Opioid, Prescription/Over the counter
Intervention Type
Drug therapy
Identification #
doi: 10.1192/pb.bp.115.052886
Page Range
pp. 314-317
Cambridge University Press
Accession Number
HRB (Electronic Only)

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