This guideline covers assessing and managing people aged 14 years and over with coexisting severe mental illness (psychosis) and substance misuse. It aims to help healthcare professionals guide people with psychosis with coexisting substance misuse to stabilise, reduce or stop their substance misuse, to improve treatment adherence and outcomes, and to enhance their lives.

NICE has also produced a guideline on coexisting severe mental illness and substance misuse: community health and social care services. 

This guideline includes recommendations on:

• principles of care
• recognising psychosis with coexisting substance misuse
• primary care
• secondary care mental health services
• substance misuse services
• inpatient mental health services and staffed accommodation
• specific issues for young people with psychosis and coexisting substance misuse

 Who is it for?

• Healthcare professionals
• People working in services delivered by the third sector and commissioned by the NHS
• People with psychosis with coexisting substance misuse, and their families and carers 

We reviewed the evidence in November 2016. We found no new evidence that affects the recommendations in this guideline.