Home > Naltrexone and acamprosate best suited to different alcohol treatment goals.

[Drug and Alcohol Findings] (2016) Naltrexone and acamprosate best suited to different alcohol treatment goals. London: Drug and Alcohol Findings. Drug and Alcohol Findings Bulletin (13 December 2016) 3 p.

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Naltrexone and acamprosate both modestly curtail drinking among alcohol-dependent patients, but which is best in which circumstances and for which treatment goals? To find out this review compared the medications’ performance when separately benchmarked against a placebo, bringing to bear much more data than is available from the few trials which directly compared the two drugs.

Key points From summary and commentary
• The medications naltrexone and acamprosate both modestly curtail drinking among alcohol-dependent patients, but it is unclear which is best in which circumstances and for which treatment goals.
• Rather than confining itself to direct comparisons of the drugs, the featured analysis addressed these issues by comparing the two medications’ performance when separately benchmarked against a placebo.
• Findings suggested naltrexone is best for patients who want to control their heavy drinking, acamprosate for those seeking abstinence. Both seem more effective when patients have detoxified and/or stopped drinking in the run-up to treatment.


Item Type:Evidence resource
Publication Type:Review
Drug Type:Alcohol
Intervention Type:AOD disorder drug therapy, AOD disorder treatment method
Source:Drug and Alcohol Findings
Date:December 2016
Pages:3 p.
Publisher:Drug and Alcohol Findings
Place of Publication:London
Number:13 December 2016
EndNote:View
Subjects:B Substances > Alcohol
B Substances > Opioids (opiates) > Opioid product > Naltrexone
G Health and disease > Substance use disorder > Alcohol use > Alcohol dependence
HJ Treatment method > Substance disorder treatment method > Substance disorder drug therapy
HJ Treatment method > Substance disorder treatment method > Substance replacement method (substitution)
HJ Treatment method > Treatment outcome

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