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Home > Naltrexone and acamprosate best suited to different alcohol treatment goals.

Drug and Alcohol Findings. (2016) Naltrexone and acamprosate best suited to different alcohol treatment goals. Drug and Alcohol Findings Research Analysis, (13 December 2016), .

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External website: http://findings.org.uk/PHP/dl.php?file=Maisel_NC_1...

Naltrexone and acamprosate both modestly curtail drinking among alcohol-dependent patients, but which is best in which circumstances and for which treatment goals? To find out this review compared the medications’ performance when separately benchmarked against a placebo, bringing to bear much more data than is available from the few trials which directly compared the two drugs.

Key points From summary and commentary
• The medications naltrexone and acamprosate both modestly curtail drinking among alcohol-dependent patients, but it is unclear which is best in which circumstances and for which treatment goals.
• Rather than confining itself to direct comparisons of the drugs, the featured analysis addressed these issues by comparing the two medications’ performance when separately benchmarked against a placebo.
• Findings suggested naltrexone is best for patients who want to control their heavy drinking, acamprosate for those seeking abstinence. Both seem more effective when patients have detoxified and/or stopped drinking in the run-up to treatment.


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