Home > Neural basis of reward anticipation and its genetic determinants.

Jia, Tianye and Macare, Christine and Desrivières, Sylvane and Gonzalez, Dante A and Tao, Chenyang and Ji, Xiaoxi and Ruggeri, Barbara and Nees, Frauke and Banaschewski, Tobias and Barker, Gareth J and Bokde, Arun L W and Bromberg, Uli and Büchel, Christian and Conrod, Patricia J and Dove, Rachel and Frouin, Vincent and Gallinat, Jürgen and Garavan, Hugh and Gowland, Penny A and Heinz, Andreas and et al, . (2016) Neural basis of reward anticipation and its genetic determinants. Proceedings of the National Academy of Sciences of the United States of America , 113 , (14) , pp. 3879-3884.

Dysfunctional reward processing is implicated in various mental disorders, including attention deficit hyperactivity disorder (ADHD) and addictions. Such impairments might involve different components of the reward process, including brain activity during reward anticipation. We examined brain nodes engaged by reward anticipation in 1,544 adolescents and identified a network containing a core striatal node and cortical nodes facilitating outcome prediction and response preparation.

Distinct nodes and functional connections were preferentially associated with either adolescent hyperactivity or alcohol consumption, thus conveying specificity of reward processing to clinically relevant behavior. We observed associations between the striatal node, hyperactivity, and the vacuolar protein sorting-associated protein 4A (VPS4A) gene in humans, and the causal role of Vps4 for hyperactivity was validated in Drosophila. Our data provide a neurobehavioral model explaining the heterogeneity of reward-related behaviors and generate a hypothesis accounting for their enduring nature.


Item Type:Article
Date:2016
Page Range:pp. 3879-3884
Publisher:National Academy of Sciences
Volume:113
Number:14
EndNote:View
Related URLs:
Subjects:E Concepts in biomedical areas > General life processes (physiology)
G Health and disease > Disorder by cause > Genetic disorder
J Health care, prevention and rehabilitation > Risk and protective factors > Risk factors

Click here to request a copy of this literature (must be logged in)

Repository Staff Only: item control page