Home > Impaired learning from errors in cannabis users: Dorsal anterior cingulate cortex and hippocampus hypoactivity.

Carey, Susan E and Nestor, Liam and Jones, Jennifer and Garavan, Hugh and Hester, Robert (2015) Impaired learning from errors in cannabis users: Dorsal anterior cingulate cortex and hippocampus hypoactivity. Drug and Alcohol Dependence, 155, pp. 175-182. 10.1016/j.drugalcdep.2015.07.671.

METHODS:
Fifteen chronic cannabis users (four females, mean age=22.40 years) and 15 control participants (two females, mean age=23.27 years) were administered a paired associate learning task that enabled participants to learn from their errors, during fMRI data collection.

RESULTS:
Compared with controls, chronic cannabis users showed (i) a lower recall error-correction rate and (ii) hypoactivity in the dACC and left hippocampus during the processing of error-related feedback and re-encoding of the correct response. The difference in error-related dACC activation between cannabis users and healthy controls varied as a function of error type, with the control group showing a significantly greater difference between corrected and repeated errors than the cannabis group.

CONCLUSIONS:
The present results suggest that chronic cannabis users have poorer learning from errors, with the failure to adapt performance associated with hypoactivity in error-related dACC and hippocampal regions. The findings highlight a consequence of performance monitoring dysfunction in drug abuse and the potential consequence this cognitive impairment has for the symptom of failing to learn from negative feedback seen in cannabis and other forms of dependence.


Item Type
Article
Publication Type
Irish-related, Article
Drug Type
Cannabis
Date
2015
Page Range
pp. 175-182
Publisher
Elsevier Science
Volume
155
EndNote
Related (external) link

Click here to request a copy of this literature (must be logged in)

Repository Staff Only: item control page