Home > Alcohol-related risk of suicidal ideation, suicide attempt, and completed suicide: a meta-analysis.

Darvishi, Nahid and Farhadi, Mehran and Haghtalab, Tahereh and Poorolajal, Jalal . (2015) Alcohol-related risk of suicidal ideation, suicide attempt, and completed suicide: a meta-analysis. Public Library of Science. PLoS ONE, 10 (5) e01268. DOI: 10.1371/journal.pone.0126870

URL: http://journals.plos.org/plosone/article?id=10.137...


Background

Several original studies have investigated the effect of alcohol use disorder (AUD) on suicidal thought and behavior, but there are serious discrepancies across the studies. Thus, a systematic assessment of the association between AUD and suicide is required.

Methods

We searched PubMed, Web of Science, and Scopus until February 2015. We also searched the Psycinfo web site and journals and contacted authors. We included observational (cohort, case-control, and cross-sectional) studies addressing the association between AUD and suicide. The exposure of interest was AUD. The primary outcomes were suicidal ideation, suicide attempt, and completed suicide. We assessed heterogeneity using Q-test and I2 statistic. We explored publication bias using the Egger's and Begg's tests and funnel plot. We meta-analyzed the data with the random-effects models. For each outcome we calculated the overall odds ratio (OR) or risk ratio (RR) with 95% confidence intervals (CI).

Results

We included 31 out of 8548 retrieved studies, with 420,732 participants. There was a significant association between AUD and suicidal ideation (OR=1.86; 95% CI: 1.38, 2.35), suicide attempt (OR=3.13; 95% CI: 2.45, 3.81); and completed suicide (OR=2.59; 95% CI: 1.95, 3.23 and RR=1.74; 95% CI: 1.26, 2.21). There was a significant heterogeneity among the studies, but little concern to the presence of publication bias.

Conclusions

There is sufficient evidence that AUD significantly increases the risk of suicidal ideation, suicide attempt, and completed suicide. Therefore, AUD can be considered an important predictor of suicide and a great source of premature death.

Item Type:Evidence resource
Publication Type:Review
Drug Type:Alcohol
Intervention Type:AOD disorder harm reduction
Date:May 2015
Pages:e01268
Publisher:Public Library of Science
Volume:10
Number:5
EndNote:View
Subjects:A Substance use, abuse, and dependence > Effects and consequences
B Substances > Alcohol
F Concepts in psychology > Specific attitude and behaviour > risk-taking behaviour
F Concepts in psychology > Specific attitude and behaviour > self-destructive behaviour > suicidal behaviour / suicide
G Health and disease > Substance use disorder > Alcohol use > Alcohol dependence
J Health care, prevention and rehabilitation > Health related prevention > Health information and education > Suicide prevention

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