Home > Effectiveness of bystander naloxone administration and overdose education programs: a meta-analysis.

Giglio, Rebecca E and Li, Guohua and DiMaggio, Charles J . (2015) Effectiveness of bystander naloxone administration and overdose education programs: a meta-analysis. Springer. Injury Epidemiology, 2 (10) 10.1186/s40621-015-0041-8

URL: http://www.injepijournal.com/content/2/1/10

The objective of this review was to assess the effectiveness of bystander naloxone administration and overdose education programs by synthesizing quantitative results reported in the research literature. Studies meeting predefined criteria were identified and reviewed, and their results were synthesized through meta-analysis. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated for overdose recoveries for individuals who received naloxone dispensed by non-medical community members, and the standardized mean difference was calculated for test scores of non-medical volunteers who received training in overdose management versus the scores of untrained volunteers.

Pooled data from four studies showed that naloxone administration by bystanders was associated with a significantly increased odds of recovery compared with no naloxone administration (OR = 8.58,95% CI = 3.90 to 13.25). Data from five studies of overdose education indicated that average scores were significantly higher for trained participants than untrained participants for tests on naloxone administration, overdose recognition, and overdose response (standardized mean difference = 1.35, 95% CI = 0.92 to 1.77). Empirical evidence in the research literature suggests that bystander naloxone administration and overdose education programs are associated with increased odds of recovery and with improved knowledge of overdose recognition and management in non-clinical settings.


Item Type:Evidence resource
Publication Type:Review
Drug Type:Opioid
Intervention Type:AOD disorder harm reduction
Date:2015
Publisher:Springer
Volume:2
Number:10
EndNote:View
Subjects:B Substances > Opioids (opiates) > Opioid product > Naloxone
G Health and disease > Substance use disorder > Drug use > Drug intoxication > Poisoning (overdose)
J Health care, prevention and rehabilitation > Substance use prevention > Substance use harm reduction
MP-MR Policy, planning, economics, work and social services > Policy > Policy on substance use > Harm reduction policy
VA Geographic area > United States

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