Home > Genetic dissection of the psychotomimetic effects of cannabinoid exposure.

O'Tuathaigh, Colm MP and Gantois, Ilse and Waddington, John L (2014) Genetic dissection of the psychotomimetic effects of cannabinoid exposure. Progress in Neuro-psychopharmacology & Biological Psychiatry , 52 , pp. 33-40.

Cannabis use is an established risk factor for the development of schizophrenia and related psychotic disorders. Factors that may mediate susceptibility to the psychosis-inducing effects of cannabis include the age at onset of first cannabis use, genetic predisposition, as well as interaction with other environmental risk variables. Clinical and preclinical genetic studies provide increasing evidence that, in particular, genes encoding proteins implicated in dopamine signalling are implicated in the cannabis-psychosis association. In the present review, we focus on both human and animal studies which have focused on identifying the neuronal basis of these interactions. We conclude that further studies are required to provide greater mechanistic insight into the long-term and neurodevelopmental effects of cannabis use, with implications for improved understanding of the cannabis-psychosis relationship.

Item Type:Article
Date:July 2014
Page Range:pp. 33-40
Subjects:B Substances > Cannabis product (synthetic cannabinoids)
G Health and disease > State of health > Mental health
J Health care, prevention and rehabilitation > Risk and protective factors > Risk factors

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