Home > Effectiveness Bank Bulletin [naltrexone and acamprosate].

Drug and Alcohol Findings. (2013) Effectiveness Bank Bulletin [naltrexone and acamprosate]. Drug and Alcohol Findings.

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PDF (1. Naltrexone and combined behavioral intervention effects on trajectories of drinking in the COMBINE study.)
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PDF (2. Acamprosate for alcohol dependence: a sex-specific meta-analysis based on individual patient data) - Published Version
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URL: http://findings.org.uk/docs/bulletins/Bull_25_07_1...

1. Naltrexone and combined behavioral intervention effects on trajectories of drinking in the COMBINE study.
Gueorguieva R., Wu R. Donovan D. et al. Drug and Alcohol Dependence: 2010, 107, p. 221–229.
Reanalysis of the largest US study of medication-based alcoholism treatment confirms that either naltrexone or psychological therapy improved outcomes more than medical care and placebos, while the two in combination or acamprosate added little. It also revealed previously invisible benefits when certain types of patients received certain treatments.

2. Acamprosate for alcohol dependence: a sex-specific meta-analysis based on individual patient data.
Mason B.J., Lehert P. Alcoholism: Clinical and Experimental Research: 2012, 36(3), p. 497–508.
The first comprehensive analysis of whether acamprosate treatment works as well for alcohol-dependent women as for men definitively concludes that across 22 mainly European trials it has had a virtually identical impact. The analysis also reports the drug's overall impact, finding that it helps prevent heavy drinking as well as fostering abstinence.


Item Type:Evidence resource
Publication Type:Review
Drug Type:Alcohol
Intervention Type:AOD disorder drug therapy
Source:Drug and Alcohol Findings
Date:25 July 2013
Publisher:Drug and Alcohol Findings
Corporate Creators:Drug and Alcohol Findings
Volume:25 Jul
EndNote:View
Accession Number:HRB (Electronic Only)
Subjects:B Substances > Alcohol
B Substances > Opioids (opiates) > Opioid product > Naltrexone
HJ Treatment method > Substance disorder treatment method > Substance disorder drug therapy
HJ Treatment method > Substance disorder treatment method > Substance replacement method (substitution)
HJ Treatment method > Treatment outcome

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