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Home > Effectiveness Bank Bulletin [naltrexone and acamprosate].

Drug and Alcohol Findings. (2013) Effectiveness Bank Bulletin [naltrexone and acamprosate]. Drug and Alcohol Findings.

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PDF (1. Naltrexone and combined behavioral intervention effects on trajectories of drinking in the COMBINE study.)
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PDF (2. Acamprosate for alcohol dependence: a sex-specific meta-analysis based on individual patient data) - Published Version
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URL: http://findings.org.uk/docs/bulletins/Bull_25_07_1...

1. Naltrexone and combined behavioral intervention effects on trajectories of drinking in the COMBINE study.
Gueorguieva R., Wu R. Donovan D. et al. Drug and Alcohol Dependence: 2010, 107, p. 221–229.
Reanalysis of the largest US study of medication-based alcoholism treatment confirms that either naltrexone or psychological therapy improved outcomes more than medical care and placebos, while the two in combination or acamprosate added little. It also revealed previously invisible benefits when certain types of patients received certain treatments.

2. Acamprosate for alcohol dependence: a sex-specific meta-analysis based on individual patient data.
Mason B.J., Lehert P. Alcoholism: Clinical and Experimental Research: 2012, 36(3), p. 497–508.
The first comprehensive analysis of whether acamprosate treatment works as well for alcohol-dependent women as for men definitively concludes that across 22 mainly European trials it has had a virtually identical impact. The analysis also reports the drug's overall impact, finding that it helps prevent heavy drinking as well as fostering abstinence.


Item Type
Evidence resource
Publication Type
Review
Drug Type
Alcohol
Intervention Type
AOD disorder drug therapy
Date
25 July 2013
Publisher
Drug and Alcohol Findings
Corporate Creators
Drug and Alcohol Findings
Volume
25 Jul
EndNote
Accession Number
HRB (Electronic Only)

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