Home > Management of the extrahepatic symptoms of chronic hepatitis C.

McKenna, Olivia and Cunningham, Caitriona and Gissane, Conor and Blake, Catherine (2013) Management of the extrahepatic symptoms of chronic hepatitis C. American Journal of Physical Medicine & Rehabilitation, 92, (6), 504 -512. doi: 10.1097/PHM.0b013e31828cd500.

Objective: The aim of this study was to explore the feasibility and the efficacy of a physiotherapy-led exercise program in changing the health status of a sample of patients with chronic hepatitis C.

Design: A single-blind randomized controlled trial was conducted in a sample of patients with iatrogenically acquired hepatitis C in Ireland. Twenty-two participants were recruited and randomly assigned to exercise (n = 10) and control (n = 1 2) groups. Both groups received a generic exercise advice leaflet, and the exercise group attended 1 2 exercise sessions for 6 wks. A battery of physical performance measures and patient-reported outcome measures were assessed at baseline and 6 wks, with 1 -yr follow-up of the self-reported measures.

Results: Significant group by time interactions during the 6-wk period were found for pain (F<sub>1,20</sub> = 5.15, P= 0.034), grip strength (F<sub>1,20</sub> = 5.94, P = 0.024), aerobic capacity (F<sub>1,20</sub> = 5.73, P = 0.024), and depression (F<sub>1,20</sub>0 = 6.1 6, P= 0.022), with the exercise group showing greater positive change. The exercise group also had superior gains in the 36-ltem Short-Form Health Survey vitality and social function scores (P < 0.05). The short-term gains were not sustained at 1 yr.

Conclusions: This pilot study shows the feasibility of exercise in hepatitis C management, improving physical fitness, psychologic function, and quality-of-life without worsening symptoms in the short term.

Item Type
Publication Type
Irish-related, Article
Drug Type
Substances (not alcohol/tobacco), Opioid
Intervention Type
Treatment method, Harm reduction
June 2013
Identification #
doi: 10.1097/PHM.0b013e31828cd500
Page Range
504 -512
Lippincott Williams & Wilkins
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