Home > Spontaneous clearance of hepatitis C infection after liver transplantation from IL28B rs12979860 CC donors.

Chin, JL and Nicholas, RM and Russell, J and Carr, M and Connell, J. and Stewart, S and McCormick, PA (2012) Spontaneous clearance of hepatitis C infection after liver transplantation from IL28B rs12979860 CC donors. European Journal of Gastroenterology & Hepatology , 24 , (9) , pp. 1110-1112.

URL: http://journals.lww.com/eurojgh/pages/default.aspx

Genetic polymorphisms adjacent to IL28B have been previously associated with spontaneous clearance of hepatitis C virus (HCV) and a higher rate of sustained virological response to interferon-based treatment in HCV genotype 1-infected patients. A recent study has shown that patients with the CC genotype of the rs12979860 single nucleotide polymorphism upstream from the IL28B gene are more likely to clear HCV spontaneously relative to the CT or TT genotype. In the liver transplant cohort, HCV recurs almost universally in patients with detectable HCV RNA at the time of transplantation. The spontaneous clearance of HCV infection after transplant is very rare. We report two cases of spontaneous clearance of HCV genotype 1 infection after liver transplantation from homozygous IL28B CC donors. This finding may be explained by alterations in the host immune responses to HCV after transplantation with a CC donor liver, which has potential implications for donor selection in HCV-positive recipients.


Item Type:Article
Date:2012
Page Range:pp. 1110-1112
Publisher:Wolters Kluwer
Volume:24
Number:9
EndNote:View
Accession Number:HRB (Available)
Subjects:A Substance use, abuse, and dependence > Prevalence > Substance use behaviour > Alcohol consumption
G Health and disease > State of health > Physical health
G Health and disease > Disorder by cause
G Health and disease > Disorder by cause > Communicable disease > Hepatitis C
G Health and disease > Digestive system disorder > Liver disorder
VA Geographic area > Europe > Ireland

Click here to request a copy of this literature (must be logged in)

Repository Staff Only: item control page