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Home > Neurochemical enhancement of conscious error awareness.

Hester, R and Namdam, LS and O'Connell, RG and Wagner, J and Strudwick, M and Nathan, PJ and Mattingly, JB and Bellgrove, MA (2012) Neurochemical enhancement of conscious error awareness. The Journal of Neuroscience , 32 , (8) , pp. 2619-2627. PMID: 22357846.

How the brain monitors ongoing behavior for performance errors is a central question of cognitive neuroscience. Diminished awareness of performance errors limits the extent to which humans engage in corrective behavior and has been linked to loss of insight in a number of psychiatric syndromes (e.g., attention deficit hyperactivity disorder, drug addiction). These conditions share alterations in monoamine signaling that may influence the neural mechanisms underlying error processing, but our understanding of the neurochemical drivers of these processes is limited. We conducted a randomized, double blind, placebo-controlled, cross-over design of the influence of methylphenidate, atomoxetine, and citalopram on error awareness in 27 healthy participants. The error awareness task, a go/no-go response inhibition paradigm, was administered to assess the influence of monoaminergic agents on performance errors during fMRI data acquisition. A single dose of methylphenidate, but not atomoxetine or citalopram, significantly improved the ability of healthy volunteers to consciously detect performance errors. Furthermore, this behavioral effect was associated with a strengthening of activation differences in the dorsal anterior cingulate cortex and inferior parietal lobe during the methylphenidate condition for errors made with versus without awareness. Our results have implications for the understanding of the neurochemical underpinnings of performance monitoring and for the pharmacological treatment of a range of disparate clinical conditions that are marked by poor awareness of errors.

 

Item Type
Article
Date
2012
Identification #
PMID: 22357846
Page Range
pp. 2619-2627
Publisher
Baltimore
Volume
32
Number
8
EndNote
Accession Number
HRB (Not in collection)

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