Home > High uptake of hepatitis C virus treatment in HIV/hepatitis C virus co-infected patients attending an integrated HIV/hepatitis C virus clinic.

Kieran, J and Dillon, A and Farrell, G and Jackson, A and Norris, S and Mulcahy, Fiona and Bergin, C (2011) High uptake of hepatitis C virus treatment in HIV/hepatitis C virus co-infected patients attending an integrated HIV/hepatitis C virus clinic. International Journal of STD & AIDS , 22 , (10) , pp. 571-576.

Hepatitis C virus (HCV) is a major cause of liver disease in HIV-infected patients. The HCV treatment outcomes and barriers to HCV referral were examined in a centre with a HIV/HCV co-infection clinic. Patients who were antibody positive for both HIV and HCV between 1987 and January 2009 were identified. A retrospective chart review was undertaken.

Multivariate analysis was performed to assess predictors of HCV clinic referral. Data were collected on 386 HIV/HCV patients; 202/386 had been referred to the co-infection clinic and 107/202 had HCV treatment. In addition, 29/202 were undergoing pretreatment work-up. Overall sustained virologic response (SVR) was 44%; SVR was equivalent in those who acquired HIV/HCV infection from intravenous drug use (IDU) and others. On multivariate analysis, patients who missed appointments, were younger, with active IDU and advanced HIV and who were not offered HCV treatment were less likely to be referred to the clinic.

Patients attending the clinic were more likely to have been screened for hepatocellular carcinoma than those attending the general HIV service. Two-thirds of patients referred to the clinic had engaged with the HCV treatment programme. Dedicated co-infection clinics lower the threshold for treatment and improve management of liver disease in co-infected patients.


Item Type:Article
Date:2011
Page Range:pp. 571-576
Publisher:Royal Society of Medicine Press
Volume:22
Number:10
EndNote:View
Accession Number:HRB (Not in collection)
Related URLs:
Subjects:G Health and disease > Disorder by cause > Communicable disease > Hepatitis C
T Demographic characteristics > Intravenous / injecting drug user
VA Geographic area > Europe > Ireland
G Health and disease > Disorder by cause > Communicable disease > HIV infection
J Health care, prevention and rehabilitation > Health-related prevention > Health information and education > Communicable disease control

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