Key results: The studies used different instruments or ways to assess the outcomes of interest, limiting the possibility for us to combine the data. When we grouped together all trial results comparing any antipsychotic drug to placebo, we found that antipsychotics slightly increase those who stayed in treatment but they were not effective in reducing cocaine use during treatment (two studies), in sustained abstinence (three studies), or in reducing the urge to consume cocaine (four studies). The single comparisons of each drug versus placebo or versus another drug were made in few trials with small sample sizes, limiting the reliability of the results. However, among these comparisons, only quetiapine seemed to perform better than placebo in reducing cocaine use and craving, but results came only from one study with 60 participants. Information was limited on the acceptability of treatment in terms of side effects, abstinence from cocaine use and withdrawal symptoms. Overall we found no evidence supporting the clinical use of antipsychotic medications in the treatment of cocaine dependence.