Home > Anticonvulsants for cocaine dependence.

Minozzi, Silvia and Cinquini, Michela and Amato, Laura and Davoli, Marina and Farrell, Michael and Pani, Pier Paolo and Vecchi, Simona [The Cochrane Library] . (2015) Anticonvulsants for cocaine dependence. London: John Wiley & Sons, Ltd. Cochrane Database of Systematic Reviews (4) DOI: 10.1002/14651858.CD006754.pub4

URL: http://onlinelibrary.wiley.com/enhanced/doi/10.100...

Key results:
The review authors identified 20 studies with 2068 participants, 77% male, with a mean age of 36 years. The mean duration of the trials was 11.8 weeks (range eight to 24 weeks). All but two of the trials were conducted in the USA, all with outpatients. The anticonvulsant drugs studied were carbamazepine, gabapentin, lamotrigine, phenytoin, tiagabine, topiramate and vigabatrin. All studies compared anticonvulsants versus placebo.

No significant differences were found between placebo and any anticonvulsant in reducing the number of dropouts from treatment, use of cocaine, craving and severity of dependence, depression or anxiety. Side effects were slightly more frequent in the anticonvulsant groups. No current evidence supports the clinical use of anticonvulsant medications for the treatment of cocaine dependence.

Item Type:Evidence resource
Publication Type:Review
Drug Type:Cocaine
Intervention Type:AOD disorder drug therapy
Source:The Cochrane Library
Date:April 2015
Publisher:John Wiley & Sons, Ltd
Place of Publication:London
Accession Number:HRB (Electronic Only)
Subjects:B Substances > Cocaine
B Substances > New (novel) psychoactive substances > Gabapentinoids GABA (Pregabalin / Gabapentin)
HJ Treatment method > Substance disorder treatment method > Substance disorder drug therapy
J Health care, prevention and rehabilitation > Health care administration > Health care quality control

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