Gulmez, Sinem Ezgi and Larrey, Dominique and Pageaux, Georges-Philippe and Bernuau, Jacques and Bissoli, Franco and Horsmans, Yves and Thorburn, Douglas and McCormick, P Aiden and Stricker, Bruno and Toussi, Massoud and Lignot-Maleyran, Séverine and Micon, Sophie and Hamoud, Fatima and Lassalle, Régis and Jové, Jérémy and Blin, Patrick and Moore, Nicholas (2015) Liver transplant associated with paracetamol overdose: results from the seven-country SALT study. British Journal of Clinical Pharmacology, 80, (3), pp. 599-606. DOI: 10.1111/bcp.12635.
All adult overdose-related acute liver failure leading to registration for transplantation (ALFT), with or without suicidal intent, in France, Greece, Ireland, Italy, the Netherlands, Portugal and the UK between 2005 and 2007 were identified from liver transplant registries and hospital records. These were compared with whole-country and per capita use of paracetamol.
Conclusions: Paracetamol overdose was found to represent one-sixth of all-cause ALFT. There was a 50-fold difference in Europe in the rates of paracetamol overdose ALFT, and a 200-fold difference per million inhabitants.
F Concepts in psychology > Behaviour > Self-destructive behaviour / self-harm > Suicidal behaviour / suicide
G Health and disease > Substance use disorder > Drug use disorder > Drug intoxication > Poisoning (overdose)
G Health and disease > Digestive system disease > Liver disease
J Health care, prevention, harm reduction and treatment > Risk and protective factors > Risk factors
VA Geographic area > Europe
VA Geographic area > Europe > Ireland
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