The National Drug Treatment Reporting System (NDTRS) is an epidemiological database on treated problem drug and alcohol use in Ireland. It was established in 1990 in the Greater Dublin Area and was extended in 1995 to cover the whole country. The reporting system was originally developed in line with the Pompidou Group’s Definitive Protocol, and was subsequently refined in accordance with the European Monitoring Centre for Drug and Drug Addiction (EMCDDA) Treatment Demand Indicator Protocol. The NDTRS is coordinated by staff at the Health Research Board (HRB) on behalf of the Department of Health.