by Delphine B. Maurel, Stéphane Pallu, Christelle Jaffré, Nicola L. Fazzalari, Nathalie Boisseau, Rustem Uzbekov, Claude-Laurent Benhamou, Gaël Y. Rochefort
Abstract:
Aims: We carried out an in vivo study to assess the relationship between increase in adiposity in the marrow and osteocyte apoptosis in the case of alcohol-induced bone loss. Methods and results: After alcohol treatment, the number of apoptotic osteocytes was increased and lipid droplets were accumulated within the osteocytes, the bone marrow and the cortical bone micro-vessels. At last, we found an inverse correlation between bone mineral density and osteocyte apoptosis and strong significant correlations between the osteocyte apoptotic number and lipid droplet accumulation in osteocyte and bone micro-vessels. Conclusion: These data show that alcohol-induced bone loss is associated with osteocyte apoptosis and lipid accumulation in the bone tissue. This lipid intoxication, or ‘bone steatosis’, is correlated with lipid accumulation in bone marrow and blood micro-vessels.
Reference:
Osteocyte Apoptosis and Lipid Infiltration as Mechanisms of Alcohol-Induced Bone Loss (Delphine B. Maurel, Stéphane Pallu, Christelle Jaffré, Nicola L. Fazzalari, Nathalie Boisseau, Rustem Uzbekov, Claude-Laurent Benhamou, Gaël Y. Rochefort), In Alcohol and Alcoholism, volume 47, no. 4, 2012.AbstractAims: We carried out an in vivo study to assess the relationship between increase in adiposity in the marrow and osteocyte apoptosis in the case of alcohol-induced bone loss. Methods and results: After alcohol treatment, the number of apoptotic osteocytes was increased and lipid droplets were accumulated within the osteocytes, the bone marrow and the cortical bone micro-vessels. At last, we found an inverse correlation between bone mineral density and osteocyte apoptosis and strong significant correlations between the osteocyte apoptotic number and lipid droplet accumulation in osteocyte and bone micro-vessels. Conclusion: These data show that alcohol-induced bone loss is associated with osteocyte apoptosis and lipid accumulation in the bone tissue. This lipid intoxication, or ‘bone steatosis’, is correlated with lipid accumulation in bone marrow and blood micro-vessels.
Bibtex Entry:
@article{doi:10.1093/alcalc/ags057,
author = {Maurel, Delphine B. and Pallu, Stéphane and Jaffré, Christelle and Fazzalari, Nicola L. and Boisseau, Nathalie and Uzbekov, Rustem and Benhamou, Claude-Laurent and Rochefort, Gaël Y.},
title = {Osteocyte Apoptosis and Lipid Infiltration as Mechanisms of Alcohol-Induced Bone Loss},
journal = {Alcohol and Alcoholism},
volume = {47},
number = {4},
pages = {413},
year = {2012},
doi = {10.1093/alcalc/ags057},
URL = {http://dx.doi.org/10.1093/alcalc/ags057},
eprint = {https://academic.oup.com/oup/backfile/content_public/journal/alcalc/47/4/10.1093/alcalc/ags057/2/ags057.pdf}
,abstract = {<strong>Aims:</strong> We carried out an in vivo study to assess the relationship between increase in adiposity in the marrow and osteocyte apoptosis in the case of alcohol-induced bone loss. <strong>Methods and results:</strong> After alcohol treatment, the number of apoptotic osteocytes was increased and lipid droplets were accumulated within the osteocytes, the bone marrow and the cortical bone micro-vessels. At last, we found an inverse correlation between bone mineral density and osteocyte apoptosis and strong significant correlations between the osteocyte apoptotic number and lipid droplet accumulation in osteocyte and bone micro-vessels. <strong>Conclusion:</strong> These data show that alcohol-induced bone loss is associated with osteocyte apoptosis and lipid accumulation in the bone tissue. This lipid intoxication, or ‘bone steatosis’, is correlated with lipid accumulation in bone marrow and blood micro-vessels.},issn = 1464-3502}