eprintid: 28023 rev_number: 7 eprint_status: archive userid: 1684 dir: disk0/00/02/80/23 datestamp: 2017-10-20 13:14:25 lastmod: 2017-10-20 13:14:25 status_changed: 2017-10-20 13:14:25 type: article metadata_visibility: show creators_name: Fabre, Aurélie creators_name: Treacy, Ann creators_name: Lavelle, Lisa P creators_name: Narski, Maciek creators_name: Faheem, Nazia creators_name: Healy, David creators_name: Dodd, Jonathan D creators_name: Keane, Michael P creators_name: Egan, James J creators_name: Jebrak, Gilles creators_name: Mal, Hervé creators_name: Butler, Marcus W browse_creators: Fabre:Aurélie:: title: Smoking-Related Interstitial Fibrosis: Evidence of Radiologic Regression with Advancing Age and Smoking Cessation. ispublished: pub subjects: BD subjects: GA4 subjects: VH4-2 full_text_status: none abstract: More data are needed regarding the radiology, co-morbidities and natural history of smoking-related interstitial fibrosis (SRIF), a common pathological finding, mainly described heretofore in association with lung cancer, where respiratory bronchiolitis (RB) usually co-exists. We prospectively acquired high resolution CT scan data (edge-enhancing lung reconstructions) to detect any radiologic interstitial lung abnormality (ILA) in individuals who ultimately underwent surgical lobectomy for lung cancer (n = 20), for radiologic/pathologic correlation. We also re-examined other smoking-related benign histologic cases: chronic obstructive pulmonary disease (COPD lung explants, n = 20), alpha 1-antitrypsin deficiency (A1AT, explanted lungs n = 20), combined pulmonary fibrosis and emphysema (CPFE, n = 8) and idiopathic pulmonary fibrosis (IPF, n = 10). Finally, we pooled our data with all peer-reviewed published data describing histologic SRIF of known ILA status. SRIF was observed in 40% of cancer lobectomies, mean (±SD) age 65.8 ± 8.7 years, none of whom had ILA. SRIF was observed in other smoking-related benign diseases (COPD 35%, A1AT 20%, CPFE 25%, and IPF 10%). 71.4% of benign SRIF cases had no RB (nearly all ex-smokers) versus 0% of cancer-associated SRIF cases (P = 1.7 × 10(-3)). Pooled data showed that those SRIF subjects without ILA were 15.05 years older than those with ILA (95% confidence interval 8.99 to 21.11, P = 2.5 × 10(-5)) and more likely to be former smokers (P = 7.2 × 10(-3)). SRIF is frequently found without lung cancer, and mostly without RB in former smokers. SRIF is less likely to have ILA in older subjects and with smoking cessation, which could represent RB+/-SRIF regression. date: 2017-10-18 date_type: published browse_by: Fabre Aurélie publication: COPD publisher: Taylor & Francis pagerange: 1-7 refereed: TRUE issn: 1541-2563 related_url_url: http://www.tandfonline.com/doi/full/10.1080/15412555.2017.1378631 related_url_type: pub request_form: display_in_all_cases doc_order_by: 1 jv_volume: unspecified jv_pub: COPD vol_subject_list: BD , GA4 , VH4-2 vol_subject_list_words: B Drugs and alcohol substances > Tobacco (cigarette smoking) -- G Health and disease > Public health vol_subject_list_geo_words: VA Geographic area > Europe > Ireland vol_subject_list_words_last: Tobacco (cigarette smoking) -- Public health vol_subject_list_geo_words_last: Europe - Ireland ace_words: Fabre Aurélie , Treacy Ann , Lavelle Lisa P , Narski Maciek , Faheem Nazia , Healy David , Dodd Jonathan D , Keane Michael P , Egan James J , Jebrak Gilles , Mal Hervé , Butler Marcus W sticky: 0 home_hide: yes citation: Fabre, Aurélie and Treacy, Ann and Lavelle, Lisa P and Narski, Maciek and Faheem, Nazia and Healy, David and Dodd, Jonathan D and Keane, Michael P and Egan, James J and Jebrak, Gilles and Mal, Hervé and Butler, Marcus W (2017) Smoking-Related Interstitial Fibrosis: Evidence of Radiologic Regression with Advancing Age and Smoking Cessation. COPD , pp. 1-7.