This report outlines the North Eastern Health Board's (NEHB) approach to education, prevention and care for drug use. As part of the process informing health promotion policy in the NEHB, 1,516 pupils from 21 schools in Meath, Louth, Cavan and Monaghan were queried on drug use, smoking and alcohol. Lifetime prevalence rates ranged between 39% at age 13 years or younger and 64% at age 16. The lifetime prevalence for smoking was higher in the NEHB than 1993 national rates for both male and female adolescents. Lifetime prevalence rates ranged between 44% at age 13 or younger and 91% at age 17 or older, with an average of 73% for all ages. Solvents and cannabis reported the highest use, with 9.6% sporadically using solvents and 10.2% cannabis. Cannabis had the highest figure for regular use with 9.5%. The questionnaire showed that adolescents offered drugs typically by friends. The outlines actions in combating adolescent smoking, alcohol and drug use through prevention and education as well as demand reduction and treatment.