This report provides a first look at the emergence of more problematic forms of use of new psychoactive substances among a range of demographic groups, including opioid and amphetamine injectors, prisoners, the homeless and men who have sex with men. It explores, in particular, the use of synthetic cathinones, synthetic cannabinoids and new synthetic opioids, as well as related harms and responses.

Table of contents

• Study rationale and methods
• The substances: which NPS are linked with high-risk use?
• NPS use among high-risk drug users
• NPS-related harms and deaths
• Discussion
• Conclusion: an uncertain future
• Acknowledgements
• References