Kertes, Darlene A. and Kalsi, Gursharan and Prescott, Carol A and Kuo, Po-Hsiu and Patterson, Diana G and Walsh, Dermot and Kendler, Kenneth S and Riley, Brien P. (2011) Neurotransmitter and neuromodulator genes associated with a history of depressive symptoms in individuals with alcohol dependence. Alcoholism Clinical and Experimental Research, 25 (3). pp. 496-505.
Background: Depressive symptoms are common among individuals with alcohol use disorders and impact treatment outcome. Substantial overlap exists among the neurobiological systems proposed in the pathophysiology of depressive and alcohol use disorders; however, specific genetic effects contributing to risk for depressive comorbidity remain poorly understood. Methods: This study examines the association of depressive symptom scores for lifetime depression (the sum of DSM-IV major depression co-endorsed criteria for lifetime depression) with markers in 120 candidate genes in 554 alcohol-dependent individuals. The candidate genes code for molecules involved in dopamine, serotonin, glutamate, gamma-aminobutyric acid (GABA), and opioid neurotransmission, cell signaling, pharmacokinetics, stress biology, and behavioral control. Analyses were conducted at the single marker level with experimentwise permutation to control for multiple testing.
Results: Results revealed nominal associations for markers in 20 genes. Following experimentwise permutation, markers in the corticotropin-releasing hormone-binding protein (CRHBP) the μ-opioid receptor (OPRM1) and the β1 subunit of GABA A (GABA(A) ) receptors (GABRB1) met or exceeded the significance threshold. None of the markers associated with depressive symptom scores were significantly associated with alcohol dependence symptom scores. Conclusion: These findings suggest potential risk genes for depressive symptoms in alcohol-dependent individuals.
|Page Range:||pp. 496-505|
|Accession Number:||HRB (Electronic Only)|
|Subjects:||VA Geographic area > Europe > Ireland|
G Health and disease > AOD related disorder > Dual diagnosis (comorbidity)
G Health and disease > Disorder by cause > Genetic disorder
G Health and disease > AOD related disorder > AOD related mental disorder
E Concepts in biomedical areas > General life processes (physiology)
Repository Staff Only: item control page